Rabbit Tau Polyclonal Antibody | anti-phospho-Tau antibody

Anti-phospho-Tau (Thr205)

Cat. Num. AAA516257

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity chromatography
• Synonyms: Tau; Polyclonal Antibody; Anti-phospho-Tau (Thr205); anti-phospho-Tau antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit, IgG
• Specificity: Recognizes the Tau protein phosphorylated at threonine 205
• Purity/Purification: Affinity chromatography
• Form/Format: PBS (pH7.4) 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Applicable Applications for anti-phospho-Tau antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr205
• Preparation and Storage: Store at 4 degree C (add 0.1% NaN3) for several months, and at -20 degree C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Western Blot (WB)

(Sample Data: Western blot analysis of extracts mouse brain using Tau antibody (lanes 1 and 2) and anti-phospho-Tau (Thr205) antibody (lanes 3 and 4).)

Related Product Information for anti-phospho-Tau antibody

The Tau family of proteins interacts directly with microtubules to stabilize macromolecular structures. Microtubule association is dependent on the phosphorylation state of Tau proteins (1). Hyperphosphorylated Tau proteins are implicated in Alzheimer's disease (AD) where it is a major component of the offending protein aggregates. Other components of the aggregates include misfolded proteins such as beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases. Malfunctioning Tau proteins are associated with microtubule disintegration and collapse of the neuronal transport system (2).

Product Categories/Family for anti-phospho-Tau antibody

Phospho Specific Antibodies; Invasion/Metastasis; Neurobiology; p38 Pathway

References

1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.
2. Rial, A. et al: Calcium Dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes. J. Biol. Chem., 2004; 279: 3524-53532.