CARD9 Antibody | anti-CARD9 antibody

CARD9 Antibody

Cat. Num. AAA8517554

• Gene Names: CARD9; CANDF2; hCARD9
• Synonyms: CARD9; CARD9 Antibody; anti-CARD9 antibody

• Sequence Length: 536

Western Blot (WB)

(Western blot analysis CARD9 using K562 whole cell lysates)

NCBI and Uniprot Product Information

• NCBI GI #: 47717131
• NCBI GeneID: 64170
• NCBI Accession #: NP_434700.2
• NCBI GenBank Nucleotide #: NM_052813.4
• UniProt Accession #: Q9H257; Q5SXM5; Q5SXM6; Q9H854
• Molecular Weight: 42,953 Da
• NCBI Official Full Name: caspase recruitment domain-containing protein 9 isoform 1
• NCBI Official Synonym Full Names: caspase recruitment domain family member 9
• NCBI Official Symbol: CARD9
• NCBI Official Synonym Symbols: CANDF2; hCARD9
• NCBI Protein Information: caspase recruitment domain-containing protein 9
• UniProt Protein Name: Caspase recruitment domain-containing protein 9
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD9
• UniProt Synonym Gene Names: hCARD9

NCBI Description

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

Uniprot Description

Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.