TSC2 antibody kit

Phospho-TSC2 Antibody Sampler Kit

Cat. Num. AAA2550084

• Gene Names: Tsc2; Rc
• Applications: Western Blot
• Synonyms: TSC2; Phospho-TSC2 Antibody Sampler Kit; TSC2 antibody kit

• Sequence Length: 1

• Applicable Applications for TSC2 antibody kit: Western Blot (WB)

Western Blot (WB)

(Western Blot analysis of 293 cells using Tuberin Polyclonal Antibody at dilution of 1:1000.)

Western Blot (WB)

(Western Blot analysis of 293 cells with Phospho-Tuberin (Ser939) Polyclonal Antibody.)

Related Product Information for TSC2 antibody kit

Background: Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.

NCBI and Uniprot Product Information

• NCBI GI #: 4432962
• NCBI GeneID: 24855
• Molecular Weight: 194,006 Da
• NCBI Official Full Name: Tsc2, partial
• NCBI Official Synonym Full Names: TSC complex subunit 2
• NCBI Official Symbol: Tsc2
• NCBI Official Synonym Symbols: Rc
• NCBI Protein Information: tuberin
• UniProt Protein Name: Tuberin
• Protein Family: Tuberin
• UniProt Gene Name: Tsc2

NCBI Description

acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]

Uniprot Description

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.