Western Blot (WB)
(Western Blot analysis of various cells using SH-PTP2 Polyclonal Antibody at dilution of 1:2000.)
SHP-2 antibody kit
SHP-2 Antibody Sampler Kit
Applications
Western Blot
Synonyms
SHP-2; SHP-2 Antibody Sampler Kit; SHP-2 antibody kit
Sequence Length
593
Applicable Applications for SHP-2 antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of various cells using SH-PTP2 Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of various cells using SH-PTP2 Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with Phospho-SH-PTP2 (Tyr542) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of HuvEc cells with Phospho-SH-PTP2 (Tyr542) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Phospho-SH-PTP2 (Tyr580) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Phospho-SH-PTP2 (Tyr580) Polyclonal Antibody)
Related Product Information for SHP-2 antibody kit
Background: SHP-2 (PTPN11) is a ubiquitously expressed, nonreceptor protein tyrosine phosphatase (PTP). It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens, and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. In addition to its role in Gab1-mediated Erk activation, SHP-2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 at p85 binding sites. SHP-2 becomes phosphorylated at Tyr542 and Tyr580 in its carboxy-terminus in response to growth factor receptor activation. These phosphorylation events are thought to relieve basal inhibition and stimulate SHP-2 tyrosine phosphatase activity. Mutations in the corresponding gene result in a pair of clinically similar disorders (Noonan syndrome and LEOPARD syndrome) that may result from abnormal MAPK regulation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
SHP-2
Similar Products
Product Notes
The SHP-2 (Catalog #AAA2550076) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SHP-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the SHP-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHP-2, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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