Western Blot (WB)
(Western Blot analysis of Mouse brain, Rat musle using Cleaved-Notch 1 (V1754) Polyclonal Antibody at dilution of 1:500.)
Notch Isoform Antibody Kit
Notch Isoform Antibody Sampler Kit
Applications
Western Blot
Synonyms
Notch Isoform; Notch Isoform Antibody Sampler Kit; Notch Isoform antibody kit
Applicable Applications for Notch Isoform antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Mouse brain, Rat musle using Cleaved-Notch 1 (V1754) Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of Mouse brain, Rat musle using Cleaved-Notch 1 (V1754) Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of HT-29 cell using NOTCH1 Polyclonal Antibody at dilution of 1:600)
Western Blot (WB)
(Western Blot analysis of HT-29 cell using NOTCH1 Polyclonal Antibody at dilution of 1:600)
Western Blot (WB)
(Western Blot analysis of Jurkat cells using Cleaved-Notch 2 (A1734) Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of Jurkat cells using Cleaved-Notch 2 (A1734) Polyclonal Antibody at dilution of 1:2000.)
Related Product Information for Notch Isoform antibody kit
Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand- binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Constitutively activated Notch1 signaling is associated with the majority of cases of T cell acute lymphoblastic leukemia (T-ALL). The activation is either due to mutations in Notch1 itself or in the components of ubiquitin ligase complex, namely FBW7. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome. Notch3 is a member of the Notch family and is processed similar to Notch1. It is expressed primarily in arterial smooth muscle cells (SMC). Mutations altering the number of cysteine residues in the notch3 extracellular region are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy leading to strokes and dementia in adults. Recent studies indicate that Notch3 is overexpressed in many types of cancer.
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Product Notes
The Notch Isoform (Catalog #AAA2550100) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Notch Isoform can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Notch Isoform for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Notch Isoform, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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