Western Blot (WB)
(Western Blot analysis of Mouse brain tissue using HOMER1 Polyclonal Antibody at dilution of 1:400)
Neuronal Scaffold Proteins Antibody Kit
Neuronal Scaffold Proteins Antibody Sampler Kit
Applications
Western Blot
Synonyms
Neuronal Scaffold Proteins; Neuronal Scaffold Proteins Antibody Sampler Kit; Neuronal Scaffold Proteins antibody kit
Applicable Applications for Neuronal Scaffold Proteins antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Mouse brain tissue using HOMER1 Polyclonal Antibody at dilution of 1:400)
Western Blot (WB)
(Western Blot analysis of Mouse brain tissue using HOMER1 Polyclonal Antibody at dilution of 1:400)
Western Blot (WB)
(Western Blot analysis of 293T cells using PSD-95 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of 293T cells using PSD-95 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of RAW264.7 cells with Shank 2 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of RAW264.7 cells with Shank 2 Polyclonal Antibody.)
Related Product Information for Neuronal Scaffold Proteins antibody kit
Background: Scaffold proteins are composed of protein-interaction domains that tether multiple components of a signaling pathway to form signal transduction complexes. This organization of signaling molecules can help enhance signaling specificity and speed. Scaffold proteins are central components in neuronal synapses, where dynamic trafficking of synaptic proteins occurs. Mutations in scaffold proteins could have significant impact on synaptic structure and function. Postsynaptic density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins and a scaffolding protein involved in the assembly and function of the postsynaptic density complex. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD), where they play a critical role in PSD assembly of excitatory synapses during development. While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer, proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins. Homer proteins are scaffolds, composed of an EVH protein-binding domain, a coiled-coil domain and a leucine zipper domain. The EVH domain is a protein-protein binding module that binds to the proline-rich motifs of G-protein-coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels. The coiled-coil and the leucine zipper domains cause multimerization of Homers and assemble signaling proteins complexes. Spinophilin is a protein phosphatase 1 regulatory protein that interacts with a large number of proteins, including ion channel components and G- protein-coupled receptors (GPCRs). Spinophilin also interacts with actin filaments; phosphorylation of spinophilin at Ser94 and Ser177 disrupts this interaction.
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Product Notes
The Neuronal Scaffold Proteins (Catalog #AAA2550147) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Neuronal Scaffold Proteins can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Neuronal Scaffold Proteins for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuronal Scaffold Proteins, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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