Western Blot (WB)
(Western Blot analysis of Hela cell and Mouse lung tissue using PTCH1 Polyclonal Antibody at dilution of 1:900)
Hedgehog Signaling Antibody Kit
Hedgehog Signaling Antibody Sampler Kit
Applications
Western Blot
Synonyms
Hedgehog Signaling; Hedgehog Signaling Antibody Sampler Kit; Hedgehog Signaling antibody kit
Applicable Applications for Hedgehog Signaling antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Hela cell and Mouse lung tissue using PTCH1 Polyclonal Antibody at dilution of 1:900)
Western Blot (WB)
(Western Blot analysis of Hela cell and Mouse lung tissue using PTCH1 Polyclonal Antibody at dilution of 1:900)
Western Blot (WB)
(Western Blot analysis of Jurkat cell using SUFU Polyclonal Antibody at dilution of 1:100)
Western Blot (WB)
(Western Blot analysis of Jurkat cell using SUFU Polyclonal Antibody at dilution of 1:100)
Western Blot (WB)
(Western Blot analysis of 1) Mouse liver, 2) Hela using GLI-1 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of 1) Mouse liver, 2) Hela using GLI-1 Polyclonal Antibody at dilution of 1:1000.)
Related Product Information for Hedgehog Signaling antibody kit
Background: The evolutionarily conserved Hedgehog (Hh) signaling pathway plays critical roles in the regulation of patterning, growth, and cell migration during embryonic development and adult tissue homeostasis. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers. The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh), and Desert (Dhh), all of which have distinct as well as overlapping roles. Patched1 and 2 (PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the Hh receptors. The general organization of the Hh pathway consists of a series of repressive interactions. In the absence of Hh proteins (off-state), PTCH suppresses the otherwise constitutively active signaling receptor Smoothened (Smo). In the off-state, SUFU (Suppressor of Fused), originally identified in Drosophila as a suppressor of the Fused (Fu) kinase, suppresses Hh signaling by regulating the localization of the transcription factors Gli and Ci. In Drosophila, SUFU may also positively regulate Hh signaling depending on SUFU protein levels and Hh signal intensity.
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Product Notes
The Hedgehog Signaling (Catalog #AAA2550106) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Hedgehog Signaling can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Hedgehog Signaling for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hedgehog Signaling, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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