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Western Blot (WB)
(Western Blot analysis of Hela, PC-3 cells using HSP A5 Polyclonal Antibody at dilution of 1:2000.)
ER Protein Folding Antibody Kit
ER Protein Folding Antibody Sampler Kit
Applications
Western Blot
Synonyms
ER Protein Folding; ER Protein Folding Antibody Sampler Kit; ER Protein Folding antibody kit
Applicable Applications for ER Protein Folding antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Hela, PC-3 cells using HSP A5 Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of Hela, PC-3 cells using HSP A5 Polyclonal Antibody at dilution of 1:2000.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer using ERP44 Polyclonal Antibody at dilution of 1/35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer using ERP44 Polyclonal Antibody at dilution of 1/35)
Western Blot (WB)
(Western Blot analysis of A549, HT29, K562 cells with ERp57 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of A549, HT29, K562 cells with ERp57 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of HepG2 cells using ERp72 Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of HepG2 cells using ERp72 Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of K562 cells using Endoplasmin Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of K562 cells using Endoplasmin Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of HEK-293 cells using PDI Monoclonal Antibody at dilution of 1:50000)
Western Blot (WB)
(Western Blot analysis of HEK-293 cells using PDI Monoclonal Antibody at dilution of 1:50000)
Related Product Information for ER Protein Folding antibody kit
Background: After their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds. This process is called oxidative protein folding. Disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds. Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange. This event is then followed by PDI-catalyzed disulfide bond formation on folding proteins. Other ER resident proteins that possess the thioredoxin homology domains, including endoplasmic reticulum stress proteins 72, 57 and 44 (ERp72, ERp57 and ERp44), constitute the PDI family. The ER also contains a pool of molecular chaperones, including Grp94, to help proteins fold properly. Grp94 is a glucose-regulated protein with sequence homology to Hsp90. BiP is another chaperone whose synthesis is increased when protein folding is disturbed. BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding.
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Product Notes
The ER Protein Folding (Catalog #AAA2550117) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ER Protein Folding can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ER Protein Folding for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ER Protein Folding, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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