Muellerian-inhibiting factor (Amh) Recombinant Protein | Amh recombinant protein
Recombinant Mouse Muellerian-inhibiting factor (Amh), partial
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the transforming growth factor-beta superfamily of growth and differentiation factors. The encoded protein is produced in fetal Sertoli cells during male gonadal differentiation. The protein binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in developing male embryos. In humans, some mutations in this gene are associated with persistent Mullerian duct syndrome (PMDS). [provided by RefSeq, Apr 2013]
Uniprot Description
AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: cytoplasm; extracellular space
Molecular Function: hormone activity; receptor binding; transforming growth factor beta receptor binding
Biological Process: activation of NF-kappaB transcription factor; cell-cell signaling; Mullerian duct regression; preantral ovarian follicle growth; urogenital system development
Research Articles on Amh
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Product Notes
The Amh amh (Catalog #AAA968365) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 450-552. Partial. The amino acid sequence is listed below: DKGQDGPCAL RELSVDLRAE RSVLIPETYQ ANNCQGACRW PQSDRNPRYG NHVVLLLKMQ ARGAALGRLP CCVPTAYAGK LLISLSEERI SADHVPNMVA TEC. It is sometimes possible for the material contained within the vial of "Muellerian-inhibiting factor (Amh), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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