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Alkaline phosphatase, tissue-nonspecific isozyme Recombinant Protein | Alpl recombinant protein
Recombinant Mouse Alkaline phosphatase, tissue-nonspecific isozyme
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Description
ALPL: This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.1.3.1; Membrane protein, GPI anchor; Phosphatase (non-protein); Motility/polarity/chemotaxis
Cellular Component: extracellular space; membrane; plasma membrane; proteinaceous extracellular matrix
Molecular Function: alkaline phosphatase activity; catalytic activity; hydrolase activity; metal ion binding; phosphoric monoester hydrolase activity; protein binding; pyrophosphatase activity
Biological Process: dephosphorylation; endochondral ossification; metabolic process; osteoblast differentiation; reproductive developmental process; response to antibiotic; response to glucocorticoid stimulus
Research Articles on Alpl
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Product Notes
The Alpl alpl (Catalog #AAA1265539) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-503aa; Partial. The amino acid sequence is listed below: PEKERDPSYW RQQAQETLKN ALKLQKLNTN VAKNVIMFLG DGMGVSTVTA ARILKGQLHH NTGEETRLEM DKFPFVALSK TYNTNAQVPD SAGTATAYLC GVKANEGTVG VSAATERTRC NTTQGNEVTS ILRWAKDAGK SVGIVTTTRV NHATPSAAYA HSADRDWYSD NEMPPEALSQ GCKDIAYQLM HNIKDIDVIM GGGRKYMYPK NRTDVEYELD EKARGTRLDG LDLISIWKSF KPRHKHSHYV WNRTELLALD PSRVDYLLGL FEPGDMQYEL NRNNLTDPSL SEMVEVALRI LTKNLKGFFL LVEGGRIDHG HHEGKAKQAL HEAVEMDQAI GKAGAMTSQK DTLTVVTADH SHVFTFGGYT PRGNSIFGLA PMVSDTDKKP FTAILYGNGP GYKVVDGERE NVSMVDYAHN NYQAQSAVPL RHETHGGEDV AVFAKGPMAH LLHGVHEQNY IPHVMAYASC IGANLDHCAW AGSG. It is sometimes possible for the material contained within the vial of "Alkaline phosphatase, tissue-nonspecific isozyme, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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