AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1) Recombinant Protein | AIMP1 recombinant protein

AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1)

Cat. Num. AAA490329

• Purity: 98.15%; Multi-Step Chromatography
• Synonyms: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1); Aminoacyl tRNA Synthetase complexinteracting multifunctional protein 1 Protein; p43; SCYE1; EMAP-2; AIMP1 recombinant protein

• Host: E Coli
• Purity/Purification: 98.15%; Multi-Step Chromatography
• Form/Format: Phosphate buffered saline, pH 7.4
• Concentration: 0.50 mg/ml (varies by lot)
• Sequence Positions: 312 aa
• Sequence Length: 337

• Source: Human
• Conjugation/Tag: Unconjugated, No Tag
• Preparation and Storage: Store at -70 degree C.

SDS-Page

Related Product Information for AIMP1 recombinant protein

AIMP1, previously known as p43, is an auxiliary component of ARS multi complex and a precursor of cytokine endothelial-monocyte activating polypeptide II (EMAPII). AIMP1 is known as a cytokine working in the control of angiogenesis, inflammation and wound healing. AIMP1 also has glucagon-like hormonal activity.

References

1. Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. Hyuk-Sang Kwon et al., Journal of Cell Science, Vol.125, 4620-4629, 2012. 2. AIMP1 deficiency enhances airway hyperreactivity in mice via increased TH2 immune responses. Hye-Jin Hong et al., Clinical Immunology, Vol.143, 256-265, 2012. 3. Enhancement of Toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. Eugene Kim et al., Immunology, Vol.134, 73-81, 2011. 4. Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation. Gyuyoup Kim et al., Biochemical and Biophysical Research Communications, Vol. 397, 100-105, 2010. 5. Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). Jung Min Han et al., Cancer Letters, Vol.287, 157-164, 2010. 6. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96;Its pathological implications in lupus-like autoimmune disease. Jungmin Han et al., American Journal of Pathology, Vol.170, 2042-2054, 2007. 7. The novel cytokine p43 induces IL-12 production in macrophages via NF-{kappa}B activation, leading to enhanced IFN-gamma production in CD4+. Eugene Kim et al., J Immunol, Vol.176, 256-264, 2006. 8. Hormonal activity of AIMP1 p43 for glucose homeostasis. Sanggyu Park et al., PNAS, Vol.103, 14913-14918, 2006.

NCBI and Uniprot Product Information

• NCBI GI #: 646722389
• UniProt Accession #: O54873
• Molecular Weight: 35kDa
• NCBI Official Full Name: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
• UniProt Protein Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
• Protein Family: Aminoacyl tRNA synthase complex-interacting multifunctional protein
• UniProt Gene Name: AIMP1
• UniProt Synonym Gene Names: SCYE1

Uniprot Description

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion ().