Activator of Hsp90 ATPase-1 (AHA1) Recombinant Protein | AHA1 recombinant protein

Activator of Hsp90 ATPase-1 (AHA1), 19-337aa, Human, E Coli

Cat. Num. AAA203038

• Gene Names: AHSA1; p38; AHA1; hAha1; C14orf3
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: Activator of Hsp90 ATPase-1 (AHA1); 19-337aa; Human; E Coli; Activator of Hsp90 ATPase-1; AHA1; Activator of Hsp90 ATPase-1 (AHA1; 19-337); Activator of Hsp90 ATPase protein 1; Hsp90 co-chaperone AHA1; Activator of Hsp90 ATPase-1 Activator of 90 kDa heat shock protein ATPase homolog 1; Activator of heat shock 90kDa protein ATPase homolog 1; AHA 1; AHSA 1; AHSA1; C14orf3; HSPC322; p38.; AHA1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris pH 8.0, 2mM EDTA
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MATNVNNWHW TERDASNWST DKLKTLFLAV QVQNEEGKCE VTEVSKLDGE ASINNRKGKL IFFYEWSVKL NWTGTSKSGV QYKGHVEIPN LSDENSVDEV EISVSLAKDE PDTNLVALMK EEGVKLLREA MGIYISTLKT EFTQGMILPT MNGESVDPVG QPALKTEERK AKPAPSKTQA RPVGVKIPTC KITLKETFLT SPEELYRVFT TQELVQAFTH APATLEADRG GKFHMVDGNV SGEFTDLVPE KHIVMKWRFK SWPEGHFATI TLTFIDKNGE TELCMEGRGI PAPEEERTRQ GWQRYYFEGI KQTFGYGARL
• Sequence Length: 338

• Applicable Applications for AHA1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for AHA1 recombinant protein

The co-chaperone Aha1 (Activator of HSP90 ATPase-1) binds the middle domain of Hsp90 (amino acid 272-627) and is proposed to function as an ATPase-activating protein that competes with p23 and other co-chaperones for Hsp90 binding. Recombinant Aha1 was expressed in E. coli and purified by using conventional chromatography techniques.

Product Categories/Family for AHA1 recombinant protein

Heat Shock Proteins

References

Meyer P., et al (2004). EMBO 23 (6): 1402-10; Siligardi G., et al (2004). J Biol Chem. 270 (50): 51989-98;

NCBI and Uniprot Product Information

• NCBI GI #: 6912280
• NCBI GeneID: 10598
• NCBI Accession #: NP_036243
• NCBI GenBank Nucleotide #: NM_012111.2
• UniProt Accession #: O95433; Q96IL6; Q9P060; B2R9L2; B4DUR9
• Molecular Weight: 36.1 kDa (320 aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1
• NCBI Official Synonym Full Names: activator of HSP90 ATPase activity 1
• NCBI Official Symbol: AHSA1
• NCBI Official Synonym Symbols: p38; AHA1; hAha1; C14orf3
• NCBI Protein Information: activator of 90 kDa heat shock protein ATPase homolog 1
• UniProt Protein Name: Activator of 90 kDa heat shock protein ATPase homolog 1
• Protein Family: ATPase
• UniProt Gene Name: AHSA1
• UniProt Synonym Gene Names: C14orf3; AHA1

Uniprot Description

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).