Protein argonaute-2 (Eif2c2) Recombinant Protein | Eif2c2 recombinant protein
Recombinant Mouse Protein argonaute-2 (Eif2c2) , partial
NCBI and Uniprot Product Information
Uniprot Description
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Regulates lymphoid and erythroid development and function, and this is independent of endonuclease activity.
Research Articles on Eif2c2
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Product Notes
The Eif2c2 ago2 (Catalog #AAA1351119) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 518-819aa; Partial(Piwi Domain). The amino acid sequence is listed below: LVVVILPGKT PVYAEVKRVG DTVLGMATQC VQMKNVQRTT PQTLSNLCLK INVKLGGVNN ILLPQGRPPV FQQPVIFLGA DVTHPPAGDG KKPSIAAVVG SMDAHPNRYC ATVRVQQHRQ EIIQDLAAMV RELLIQFYKS TRFKPTRIIF YRDGVSEGQF QQVLHHELLA IREACIKLEK DYQPGITFIV VQKRHHTRLF CTDKNERVGK SGNIPAGTTV DTKITHPTEF DFYLCSHAGI QGTSRPSHYH VLWDDNRFSS DELQILTYQL CHTYVRCTRS VSIPAPAYYA HLVAFRARYH LV . It is sometimes possible for the material contained within the vial of "Protein argonaute-2 (Eif2c2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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