SDS-PAGE
Apoptosis-enhancing nuclease Recombinant Protein | AEN recombinant protein
Recombinant Human Apoptosis-enhancing nuclease
Gene Names
AEN; ISG20L1; pp12744
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Apoptosis-enhancing nuclease; Recombinant Human Apoptosis-enhancing nuclease; Interferon-stimulated 20 kDa exonuclease-like 1; AEN recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
117-325aa; Partial
Sequence
MVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN
Sequence Length
325
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for AEN recombinant protein
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancent of apoptosis.
Product Categories/Family for AEN recombinant protein
References
Zhang W., Li N., Wan T., Chen T., Zhang J., Cao X.Analysis of the DNA sequence and duplication history of human chromosome 15.Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.Nature 440:671-675(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40.1 kDa
NCBI Official Full Name
apoptosis-enhancing nuclease
NCBI Official Synonym Full Names
apoptosis enhancing nuclease
NCBI Official Symbol
AEN
NCBI Official Synonym Symbols
ISG20L1; pp12744
NCBI Protein Information
apoptosis-enhancing nuclease
UniProt Protein Name
Apoptosis-enhancing nuclease
Protein Family
UniProt Gene Name
AEN
UniProt Synonym Gene Names
ISG20L1
UniProt Entry Name
AEN_HUMAN
Uniprot Description
AEN: Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Nucleolus; Apoptosis; EC 3.1.-.-
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: nuclear membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: exonuclease activity; nucleic acid binding; protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to ionizing radiation
Research Articles on AEN
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Product Notes
The AEN aen (Catalog #AAA1340813) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 117-325aa; Partial. The amino acid sequence is listed below: MVGTGPRGRV SELARCSIVS YHGNVLYDKY IRPEMPIADY RTRWSGITRQ HMRKAVPFQV AQKEILKLLK GKVVVGHALH NDFQALKYVH PRSQTRDTTY VPNFLSEPGL HTRARVSLKD LALQLLHKKI QVGQHGHSSV EDATTAMELY RLVEVQWEQQ EARSLWTCPE DREPDSSTDM EQYMEDQYWP DDLAHGSRGG AREAQDRRN. It is sometimes possible for the material contained within the vial of "Apoptosis-enhancing nuclease, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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