Human Adenosine receptor A2a ELISA Kit | ADORA2A elisa kit

Human Adenosine receptor A2a ELISA Kit

Cat. Num. AAA2881923

• Gene Names: ADORA2A; A2aR; RDC8; ADORA2
• Reactivity: Human
• Synonyms: Adenosine receptor A2a; Human Adenosine receptor A2a ELISA Kit; ADORA2A; ADORA2; ADORA2A elisa kit

• Reactivity: Human
• Sequence Length: 412

• Assay Type: Sandwich
• Detection Range: 0.469-30 ng/mL
• Sensitivity: 0.14 ng/mL
• Intra-Assay CV: <=4.5%
• Inter-Assay CV: <=8.2%
• Recovery: 102%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 5921992
• NCBI GeneID: 135
• NCBI Accession #: NP_000666.2
• NCBI GenBank Nucleotide #: NM_000675.5
• UniProt Accession #: P29274; B2R7E0
• Molecular Weight: 44,707 Da
• NCBI Official Full Name: adenosine receptor A2a
• NCBI Official Synonym Full Names: adenosine A2a receptor
• NCBI Official Symbol: ADORA2A
• NCBI Official Synonym Symbols: A2aR; RDC8; ADORA2
• NCBI Protein Information: adenosine receptor A2a
• UniProt Protein Name: Adenosine receptor A2a
• Protein Family: Adenosine receptor
• UniProt Gene Name: ADORA2A
• UniProt Synonym Gene Names: ADORA2
• UniProt Entry Name: AA2AR_HUMAN

NCBI Description

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Uniprot Description

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled; enzyme binding; identical protein binding; protein binding

Biological Process: adenosine receptor signaling pathway; adenylate cyclase activation; apoptosis; blood circulation; blood coagulation; cAMP biosynthetic process; cell-cell signaling; cellular defense response; cellular protein metabolic process; central nervous system development; G-protein signaling, coupled to cAMP nucleotide second messenger; inflammatory response; nerve growth factor receptor signaling pathway; phagocytosis; sensory perception; transmembrane receptor protein tyrosine kinase signaling pathway