Adagio protein 2 (ADO2) Recombinant Protein | ADO2 recombinant protein

Recombinant Arabidopsis thaliana Adagio protein 2 (ADO2) , partial

• Gene Names: LKP2; ADAGIO 2; ADO2; LOV KELCH protein 2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Adagio protein 2 (ADO2); Recombinant Arabidopsis thaliana Adagio protein 2 (ADO2); partial; ADO2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 601

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 30680514
• NCBI GeneID: 816408
• NCBI Accession #: NP_565444.2
• NCBI GenBank Nucleotide #: NM_127448.2
• UniProt Accession #: Q8W420; Q9C5S6; B5X4Z7
• Molecular Weight: 65,116 Da
• NCBI Official Full Name: LOV KELCH protein 2
• NCBI Official Symbol: LKP2
• NCBI Official Synonym Symbols: ADAGIO 2; ADO2; LOV KELCH protein 2
• NCBI Protein Information: LOV KELCH protein 2
• UniProt Protein Name: Adagio protein 2
• Protein Family: Adagio protein
• UniProt Gene Name: ADO2
• UniProt Synonym Gene Names: FKL1; LKP2; FBX2c; FKF1-like protein 1

NCBI Description

encodes a member of F-box proteins that includes two other proteins in Arabidopsis (ZTL and FKF1). These proteins contain a unique structure containing a PAS domain at their N-terminus, an F-box motif, and 6 kelch repeats at their C-terminus. Overexpression results in arrhythmic phenotypes for a number of circadian clock outputs in both constant light and constant darkness, long hypocotyls under multiple fluences of both red and blue light, and a loss of photoperiodic control of flowering time. Although this the expression of this gene itself is not regulated by circadian clock, it physically interacts with Dof transcription factors that are transcriptionally regulated by circadian rhythm. LKP2 interacts with Di19, CO/COL family proteins.

Uniprot Description

Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO2) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5 seem to be substrates of the SCF(ADO2) complex. ADO2 interacts with ADO3 and export it to cytoplasmic speckles, preventing the interaction of ADO3 with CDF1. Ubiquitination of ADO2 is not involved in this recruitment.