A disintegrin and metalloproteinase with thrombospondin motifs 1 (Adamts1) Recombinant Protein | Adamts1 recombinant protein

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 1 (Adamts1)

Cat. Num. AAA1487271

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 1 (Adamts1); Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 1 (Adamts1); Adamts1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 253-967, full length protein
• Sequence: FVSSPRYVETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQKGPEVTSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCASFNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSDLPGTLYDANRQCQFTFGEESTHCPDAASTCSTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGTVTSTRPGYHDIVTIPAGATNIEVKHRNPRGSRNNGSFLAIRAADGTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKYTYFMKKKTEPFNAIPTFSEWVIEEWGECSKTCGSGWQRRVVECRDINGHPASECAKEVKPASTRPCADLPCPRWQVGDWSPCSKTCGKGYKKRTLKCLSHDGGVLSNESCDPLKKPKHYIDFCILTQCS
• Sequence Length: 715

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Adamts1 recombinant protein

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.

NCBI and Uniprot Product Information

• NCBI GI #: 11131014
• NCBI GeneID: 79252
• UniProt Accession #: Q9WUQ1; Q9ERI1
• Molecular Weight: 105,706 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 1
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 1
• NCBI Official Symbol: Adamts1
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 1
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 1
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: Adamts1
• UniProt Synonym Gene Names: ADAM-TS 1; ADAM-TS1; ADAMTS-1

NCBI Description

disintegrin and metalloprotease that may be necessary for normal kidney morphology and function [RGD, Feb 2006]

Uniprot Description

Cleaves aggrecan, a cartilage proteoglycan, at the '1683-Glu-|-Leu-1684' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture ().