Disintegrin and metalloproteinase domain-containing protein 10 (Adam10) Recombinant Protein | Adam10 recombinant protein

Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 10 (Adam10), partial

Cat. Num. AAA1127986

• Gene Names: Adam10; kuz; MADM; kuzbanian; 1700031C13Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Disintegrin and metalloproteinase domain-containing protein 10 (Adam10); Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 10 (Adam10); partial; Adam10 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 20-673
• Sequence: Q YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL LLDFHAHGRQ FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI DGRFEGFIKT RGGTFYIEPA ERYIKDRILP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE RMRKYQMTGV EEGARAHPEK HAASSGPELL RKKRTTLAER NTCQLYIQTD HLFFKYYGTR EAVIAQISSH VKAIDTIYQT TDFSGIRNIS FMVKRIRINT TSDEKDPTNP FRFPNIGVEK FLELNSEQNH DDYCLAYVFT DRDFDDGVLG LAWVGAPSGS SGGICEKSKL YSDGKKKSLN TGIITVQNYG SHVPPKVSHI TFAHEVGHNF GSPHDSGTEC TPGESKNLGQ KENGNYIMYA RATSGDKLNN NKFSLCSIRN ISQVLEKKRN NCFVESGQPI CGNGMVEQGE ECDCGYSDQC KDDCCFDANQ PEGKKCKLKP GKQCSPSQGP CCTAQCAFKS KSEKCRDDSD CAKEGICNGF TALCPASDPK PNFTDCNRHT QVCINGQCAG SICEKYDLEE CTCASSDGKD DKELCHVCCM KKMAPSTCAS TGSLQWSKQF SGRTITLQPG SPCNDFRGYC DVFMRCRLVD ADGPLARLKK AIFSPQLYEN IAE
• Sequence Length: 654

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for Adam10 recombinant protein

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.

NCBI and Uniprot Product Information

• NCBI GI #: 150378458
• NCBI GeneID: 11487
• NCBI Accession #: NP_031425.2
• NCBI GenBank Nucleotide #: NM_007399.4
• UniProt Accession #: O35598; B8JJJ0
• Molecular Weight: 83,968 Da
• NCBI Official Full Name: disintegrin and metalloproteinase domain-containing protein 10 preproprotein
• NCBI Official Synonym Full Names: a disintegrin and metallopeptidase domain 10
• NCBI Official Symbol: Adam10
• NCBI Official Synonym Symbols: kuz; MADM; kuzbanian; 1700031C13Rik
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 10
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 10
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: Adam10
• UniProt Synonym Gene Names: Kuz; Madm; ADAM 10

NCBI Description

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]

Uniprot Description

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688' (). Contributes to the normal cleavage of the cellular prion protein (). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (PubMed:9244301). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (). May regulate the EFNA5-EPHA3 signaling ().