Interleukin 4 Induced Protein 1 Active Protein | IL4I1 active protein

Interleukin 4 Induced Protein 1, Recombinant, Human (IL-4I1, FIG-1, L-amino acid oxidase)

Cat. Num. AAA650631

• Gene Names: IL4I1; FIG1
• Purity: 95% by SDS­PAGE under reducing conditions and visualized by silver stain.
• Synonyms: Interleukin 4 Induced Protein 1; Recombinant; Human (IL-4I1; FIG-1; L-amino acid oxidase); IL4I1 active protein

• Purity/Purification: 95% by SDS­PAGE under reducing conditions and visualized by silver stain.
• Form/Format: Supplied as a liquid in 20mM Tris, pH 7.5, 120mM sodium chloride, 20% glycerol.
• Concentration: 0.44mg/ml (varies by lot)

• Application Notes: Suitable for use in ELISA.
• Endotoxin Level: <1.0 EU/ug (LAL)
• Structure: Monomer
• Specific Activity: >150pmol/min/ug. Measured by its ability to oxidize phenylalanine in a horseradish peroxidase coupled assay.
• Preparation and Storage: Store at -70°C.; Aliquot to avoid repeated freezing and thawing.; Stable for 6 months after receipt at -70°C.; For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for IL4I1 active protein

Interleukin 4 induced protein 1(IL4I1), also known as protein FIG­1 and L­amino acid oxidase, is encoded by a B­cell IL4­inducible gene, FIG1, and is highly expressed in primary metastinal B­cell lymphomas (1­4). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL4I1 has L­amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hI L4I1 inhibited the proliferation of CD3­stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5). Its inhibitory effect was dependent on enzymatic activity and H2O2 production. Its restricted expression to l ymphoid tissues indicates that it may play an important function in the immune system (1, 4).

Product Categories/Family for IL4I1 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 71060513
• NCBI GeneID: 259307
• UniProt Accession #: Q96RQ9; Q4GZN1; Q4GZN2; Q6P2Q3; Q8TEM5; Q96RQ8; Q1WMJ3
• Molecular Weight: 61kD, SDS-PAGE: 70-75kD
• NCBI Official Full Name: interleukin 4 induced protein 1
• NCBI Official Synonym Full Names: interleukin 4 induced 1
• NCBI Official Symbol: IL4I1
• NCBI Official Synonym Symbols: FIG1
• NCBI Protein Information: L-amino-acid oxidase; LAO; LAAO; hFIG1; Fig-1 protein; IL4-induced protein 1; interleukin four induced 1
• UniProt Protein Name: L-amino-acid oxidase
• UniProt Gene Name: IL4I1
• UniProt Synonym Gene Names: FIG1
• UniProt Entry Name: OXLA_HUMAN

NCBI Description

The protein encoded by this gene shares the limited similarity with L-amino acid oxidase, and contains the conserved key amino acid residues thought to be involved in catalysis and binding of the flavin adenine dinucleotide cofactor. The expression of this gene can be induced by interleukin 4 in B cells. Two alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq]

Uniprot Description

Function: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation

Catalytic activity: An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactor: FAD

Subcellular location: Isoform 1: Lysosome

By similarity Ref.2. Isoform 2: Lysosome

By similarity Ref.2.

Tissue specificity: Isoform 1 is primarily found in immune tissues. Ref.1

Induction: By IL4/interleukin-4.

Sequence similarities: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Sequence caution: The sequence BAB84923.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI54291.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI54292.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI54293.1 differs from that shown. Reason: Erroneous initiation.