Interleukin 1 beta Active Protein | IL1B active protein
Interleukin 1 beta, Recombinant, Mouse (IL-1b)
Gene Names
IL1B; IL1-BETA
Purity
Highly Purified~ 98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug
Synonyms
Interleukin 1 beta; Recombinant; Mouse (IL-1b); IL1B active protein
Purity/Purification
Highly Purified
~ 98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug
~ 98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug
Form/Format
Supplied as a lyophilized powder from sodium citrate, pH 4.0.
Sequence
MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
Biological Activity
Murine IL-1b is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of murine D10S cells is 0.002ng/ml, corresponding to a specific activity of 5x10e8 units/mg.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or ddH2O containing a carrier protein. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for IL1B active protein
Interleukin-1 beta (IL-1beta) is a potent immunomodulator which mediates a wide range of immune and inflammatory responses, including the activation of B and T cells. Murine IL-1b is a 17.5kD protein containing 153 amino acid residues.
Product Categories/Family for IL1B active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17.5kD
NCBI Official Full Name
interleukin-1 beta
NCBI Official Symbol
IL1B
NCBI Official Synonym Symbols
IL1-BETA
NCBI Protein Information
interleukin-1 beta; IL-1 beta; interleukin 1 beta; lymphocyte proliferation-potentiating factor
UniProt Protein Name
Interleukin-1 beta
Protein Family
UniProt Gene Name
IL1B
UniProt Entry Name
IL1B_RABIT
Uniprot Description
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subunit structure: Monomer.
Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Sequence similarities: Belongs to the IL-1 family.
Research Articles on IL1B
Similar Products
Product Notes
The IL1B il1b (Catalog #AAA650630) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS. It is sometimes possible for the material contained within the vial of "Interleukin 1 beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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