Structure
(Heregulin-B2 structure and sequence)
Heregulin beta 2 Active Protein
Heregulin beta 2, Recombinant, Human (NRG1, Pro-neuregulin-1, Membrane-bound Isoform, Pro-NRG1, Neuregulin-1, Acetylcholine Receptor-inducing Activity, ARIA, Breast Cancer Cell Differentiation Factor p45, Glial Growth Factor, Heregulin, HRG, Neu Different
Purity
Highly Purified~95% (RP-HPLC and SDS-PAGE)
Synonyms
Heregulin beta 2; Recombinant; Human (NRG1; Pro-neuregulin-1; Membrane-bound Isoform; Pro-NRG1; Neuregulin-1; Acetylcholine Receptor-inducing Activity; ARIA; Breast Cancer Cell Differentiation Factor p45; Glial Growth Factor; Heregulin; HRG; Neu Different; Heregulin beta 2 active protein
Purity/Purification
Highly Purified
~95% (RP-HPLC and SDS-PAGE)
~95% (RP-HPLC and SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from 20mM PB, pH 7.0, 0.5%HSA, 2% mannitol. Reconstitute with sterile 18Mo-cm H2O to 100ug/ml.
Biological Activity
The ED50, calculated by the dose-dependant stimulation of human MCF-7 cells is <0.5ng/ml, corresponding to a specific activity of >2x10e6units/mg.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Structure
(Heregulin-B2 structure and sequence)
Structure
(Heregulin-B2 structure and sequence)
Related Product Information for Heregulin beta 2 active protein
Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that neuregulin recombinant could make disturbed myocardial cell structure into order and strengthen the connection between myocardial cells by intercalated discs re-organization. Pharmacodynamic experiments in animals showed that neuregulin (NRG1) recombinant can reduce the degree of damage on myocardial cells caused by ischemia, hypoxia and viral infection.
Product Categories/Family for Heregulin beta 2 active protein
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Product Notes
The Heregulin beta 2 (Catalog #AAA636312) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Heregulin beta 2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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