BD4 Active Protein
BD4, Recombinant, Human (Defensin, beta 104, HBD-4, BD-4, Beta-defensin 104, Beta-defensin 4, DEFB-4, DEFB104A, DEFB104, DEFB4, DEFB104B)
Purity
Highly Purified~98% (SDS-PAGE, HPLC)
Synonyms
BD4; Recombinant; Human (Defensin; beta 104; HBD-4; BD-4; Beta-defensin 104; Beta-defensin 4; DEFB-4; DEFB104A; DEFB104; DEFB4; DEFB104B); BD4 active protein
Purity/Purification
Highly Purified
~98% (SDS-PAGE, HPLC)
~98% (SDS-PAGE, HPLC)
Form/Format
Supplied as a lyophilized powder in 20mM PBS, pH 7.4, 130mM sodium chloride. Reconstitute with sterile dH2O to 100ug/ml.
Sequence
EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-50ng/ml.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for BD4 active protein
Defensins are cationic peptides with a large spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha defensins are differentiated from the Beta-defensins by the pairing of their 3 disulfide bonds. Four human Beta-defensins have been identified to date; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence (for BD-1 a propeptide region). Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta Defensin-4 Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 50aa. The BD-4 is purified by proprietary chromatographic techniques.
Product Categories/Family for BD4 active protein
NCBI and Uniprot Product Information
Similar Products
Product Notes
The BD4 (Catalog #AAA637490) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP. It is sometimes possible for the material contained within the vial of "BD4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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