ALDH3A1 active protein

ALDH3A1, Recombinant, Human (Aldehyde Dehydrogenase, Dimeric NADP-preferring, ALDHIII, Aldehyde Dehydrogenase 3, Aldehyde Dehydrogenase Family 3 Member A1, ALDH3)

Cat. Num. AAA637007

• Gene Names: ALDH3A1; ALDH3; ALDHIII
• Purity: Highly Purified; ~95% (SDS-PAGE)
• Synonyms: ALDH3A1; Recombinant; Human (Aldehyde Dehydrogenase; Dimeric NADP-preferring; ALDHIII; Aldehyde Dehydrogenase 3; Aldehyde Dehydrogenase Family 3 Member A1; ALDH3); ALDH3A1 active protein

• Purity/Purification: Highly Purified; ~95% (SDS-PAGE)
• Form/Format: Supplied as a liquid in Tris, sodium chloride, DTT, glycerol.

• Biological Activity: Measured by the ability to catalyze the oxidation of 4-nitrobenzaldehyde. The specific activity is >6000 pmol/min/ug, as measured under the described conditions.
• Endotoxin Level: 1EU/1ug (LAL)
• Preparation and Storage: Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for ALDH3A1 active protein

Aldehyde Dehydrogenases (ALDHs) are NAD(P)+- dependent enzymes that catalyze the oxidation of endogeneously produced and exogeneous aldehydes to their corresponding acids (1). They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and in lipid peroxidation. ALDH3A1 is also known as stomach aldehyde dehydrogenase. It exists as a homodimer, and prefers NADP+ over NAD+ as its co-factor (2). It preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates (3). The enzyme is highly expressed in stomach and cornea (2, 4). In the cornea, its proposed roles have been to absorb UV-light, reduce oxidative damage, maintain corneal refractive and transparence properties, and display chaperone-like activity (4, 5). It also has been identified as a lung cancer biomarker (6).

Product Categories/Family for ALDH3A1 active protein

Molecular Biology; MB-Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 206597441
• NCBI GeneID: 218
• NCBI Accession #: NP_001128640.1
• NCBI GenBank Nucleotide #: NM_001135168.1
• UniProt Accession #: P30838; Q9BT37; A8K828
• Molecular Weight: ~51kD
• NCBI Official Full Name: aldehyde dehydrogenase, dimeric NADP-preferring
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 3 family, member A1
• NCBI Official Symbol: ALDH3A1
• NCBI Official Synonym Symbols: ALDH3; ALDHIII
• NCBI Protein Information: aldehyde dehydrogenase, dimeric NADP-preferring; stomach aldehyde dehydrogenase; aldehyde dehydrogenase type III; aldehyde dehydrogenase isozyme 3
• UniProt Protein Name: Aldehyde dehydrogenase, dimeric NADP-preferring
• Protein Family: Aldehyde dehydrogenase
• UniProt Gene Name: ALDH3A1
• UniProt Synonym Gene Names: ALDH3
• UniProt Entry Name: AL3A1_HUMAN

NCBI Description

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Uniprot Description

ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family.

Protein type: Amino Acid Metabolism - phenylalanine; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.2.1.5; Amino Acid Metabolism - histidine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; extracellular space; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity

Biological Process: response to drug; response to cAMP; positive regulation of cell proliferation; response to glucocorticoid stimulus; response to hypoxia; aldehyde metabolic process; response to nutrient; aging