Prostatic Acid Phosphatase Active Protein | ACPP active protein
Prostatic Acid Phosphatase (PAP/ACP), Human
Appearance: Off-white powder
Custom preparations, technical support, bulk quantities and aliquoting available.
What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP,ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.
The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.
Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to prostate specific antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.
Human prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore,Human Acid Phosphatase has an acid pH optimum below 7.0.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Description
ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.
Protein type: EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11
Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane
Molecular Function: acid phosphatase activity
Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development
Disease: Acid Phosphatase Deficiency
Research Articles on ACPP
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Product Notes
The ACPP acp2 (Catalog #AAA173168) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prostatic Acid Phosphatase, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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