Cytoplasmic aconitate hydratase (Aco1) Recombinant Protein | Aco1 recombinant protein

Recombinant Rat Cytoplasmic aconitate hydratase (Aco1) , partial

• Gene Names: Aco1; AH; IRP1; Acon1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cytoplasmic aconitate hydratase (Aco1); Recombinant Rat Cytoplasmic aconitate hydratase (Aco1); partial; Aco1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 889

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Aco1 recombinant protein

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

NCBI and Uniprot Product Information

• NCBI GI #: 8394162
• NCBI GeneID: 50655
• NCBI Accession #: NP_059017.1
• NCBI GenBank Nucleotide #: NM_017321.1
• UniProt Accession #: Q63270
• Molecular Weight: 98,128 Da
• NCBI Official Full Name: cytoplasmic aconitate hydratase
• NCBI Official Synonym Full Names: aconitase 1
• NCBI Official Symbol: Aco1
• NCBI Official Synonym Symbols: AH; IRP1; Acon1
• NCBI Protein Information: cytoplasmic aconitate hydratase
• UniProt Protein Name: Cytoplasmic aconitate hydratase
• Protein Family: Cytoplasmic aconitate hydratase
• UniProt Gene Name: Aco1
• UniProt Synonym Gene Names: Ireb1; Irebp; Aconitase; IRP1; IRE-BP 1

NCBI Description

This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism [provided by RefSeq, Jan 2014]

Uniprot Description

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding ().