Specific Activity
(Binding ability measured in a functional ELISA. Unlike human ACE2. Dog ACE2 (18-739) Protein (MBS515755) does not bind well to immoblized 2019-n-Cov Spike protein RBD (MBS515722).)
ACE2 Recombinant Protein
ACE2 (18-739) Protein
Purity
> 90%
Synonyms
ACE2; ACE2 (18-739) Protein; ACEH; Angiotensin I converting enzyme 2; ACE2 recombinant protein
Host
CHO Cells
Purity/Purification
> 90%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 90mM glycine
Species
Dog
Tag
Fc
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity
(Binding ability measured in a functional ELISA. Unlike human ACE2. Dog ACE2 (18-739) Protein (MBS515755) does not bind well to immoblized 2019-n-Cov Spike protein RBD (MBS515722).)
Specific Activity
(Binding ability measured in a functional ELISA. Unlike human ACE2. Dog ACE2 (18-739) Protein (MBS515755) does not bind well to immoblized 2019-n-Cov Spike protein RBD (MBS515722).)
Purity Data
(The purity of Dog ACE2 (18-739) Protein was determined to be >90% by densitometry. approx. MW 150kDa)
Purity Data
(The purity of Dog ACE2 (18-739) Protein was determined to be >90% by densitometry. approx. MW 150kDa)
Related Product Information for ACE2 recombinant protein
Recombinant Dog ACE2 Protein (18-739) was expressed in CHO cells using a C-terminal Fc tag. The gene accession number is XM_014111329.
Overview: The angiotensin converting enzyme 2 (ACE2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases (1). ACE2 cleaves the angiotensin I and angiotensin II to counterbalancing ACE activity in the regulation of renin angiotensin system (RAS) (1). ACE2 also has the role in regulation of cardiovascular, renal and reproductive systems physiologically (1). In addition, ACE2 is a functional receptor for the spike glycoprotein (S) of SARS-CoV, HCoV-NL63, and SARS-CoV-2 (2), which causes the pandemic of the respiratory diseases (COVID-19) (3).
Overview: The angiotensin converting enzyme 2 (ACE2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases (1). ACE2 cleaves the angiotensin I and angiotensin II to counterbalancing ACE activity in the regulation of renin angiotensin system (RAS) (1). ACE2 also has the role in regulation of cardiovascular, renal and reproductive systems physiologically (1). In addition, ACE2 is a functional receptor for the spike glycoprotein (S) of SARS-CoV, HCoV-NL63, and SARS-CoV-2 (2), which causes the pandemic of the respiratory diseases (COVID-19) (3).
Product Categories/Family for ACE2 recombinant protein
References
1. Imai Y, et al: Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 2007, 74(3):405-10.
2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.
3. Zhou P, et al: A pneumonia outbreak associated with a new Corona virus of probable bat origin. Nature. 2020, 579:270-89.
2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.
3. Zhou P, et al: A pneumonia outbreak associated with a new Corona virus of probable bat origin. Nature. 2020, 579:270-89.
NCBI and Uniprot Product Information
Molecular Weight
150kDa
Protein Family
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Product Notes
The ACE2 (Catalog #AAA515755) is a Recombinant Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ACE2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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