Specific Activity
(Binding ability measured in a functional ELISA. DPP4 protein (MBS515774) can bind to immobilized MERS Spike Protein RBD (MBS515779))
MERS Spike RBD Active Protein
MERS Spike Protein RBD
Synonyms
MERS Spike RBD; MERS Spike Protein RBD; MERS Corona virus S1; Corona virus S2; Corona virus spike; cov spike; ncov S1; ncov S2; ncov RBD; Spike RBD; RBD; MERS Spike RBD active protein
Host
CHO Cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 90mM glycine
Species
MERS-CoV
Tag
Fc
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity
(Binding ability measured in a functional ELISA. DPP4 protein (MBS515774) can bind to immobilized MERS Spike Protein RBD (MBS515779))
Specific Activity
(Binding ability measured in a functional ELISA. DPP4 protein (MBS515774) can bind to immobilized MERS Spike Protein RBD (MBS515779))
Purity Data
(The purity of MERS Spike Protein RBD was determined to be >90% by densitometry, approx. MW 58 kDa.)
Purity Data
(The purity of MERS Spike Protein RBD was determined to be >90% by densitometry, approx. MW 58 kDa.)
Related Product Information for MERS Spike RBD active protein
Recombinant MERS Spike Protein RBD (377-588) was expressed in CHO cells using a C-terminal human IgG1 Fc tag. The gene accession number is KU696644.
Overview: The Middle East respiratory syndrome Corona virus (MERS-CoV) has caused the MERS outbreak that first originated in Saudi Arabia, but since has spread to other countries around the world (1). The spike glycoprotein (S) of Corona virus belongs to the type I transmembrane protein containing two subunits (2), S1 and S2, which is known to be the key component to bind with host cells through interaction with dipeptidyl peptidase 4 (DPP4) (3). MERS-CoV can recognize DPP4 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (2).
Overview: The Middle East respiratory syndrome Corona virus (MERS-CoV) has caused the MERS outbreak that first originated in Saudi Arabia, but since has spread to other countries around the world (1). The spike glycoprotein (S) of Corona virus belongs to the type I transmembrane protein containing two subunits (2), S1 and S2, which is known to be the key component to bind with host cells through interaction with dipeptidyl peptidase 4 (DPP4) (3). MERS-CoV can recognize DPP4 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (2).
Product Categories/Family for MERS Spike RBD active protein
References
1. Mohd H, et al: Middle East Respiratory Syndrome Corona virus (MERS-CoV) origin and animal reservoir. Viral J. 2016, 13: 87.
2. Lu G, et al: Molecular basis of binding between novel human Corona virus MERS-CoV and its receptor CD26. Nature. 2013, 500: 227-231.
3. Al-Tawfiq et al: Middle East Respiratory Syndrome-Corona virus (MERS-CoV) Infection. Emerging Infectious Diseases. 2014, 185-190.
2. Lu G, et al: Molecular basis of binding between novel human Corona virus MERS-CoV and its receptor CD26. Nature. 2013, 500: 227-231.
3. Al-Tawfiq et al: Middle East Respiratory Syndrome-Corona virus (MERS-CoV) Infection. Emerging Infectious Diseases. 2014, 185-190.
NCBI and Uniprot Product Information
UniProt Accession #
Molecular Weight
58kDa
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Product Notes
The MERS Spike RBD (Catalog #AAA515779) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MERS Spike RBD, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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