Acetyl-Coenzyme A acetyltransferase 2 Recombinant Protein | ACAT2 recombinant protein

Recombinant Human Acetyl-Coenzyme A acetyltransferase 2

Cat. Num. AAA142436

• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Acetyl-Coenzyme A acetyltransferase 2; Recombinant Human Acetyl-Coenzyme A acetyltransferase 2; ACAT2 Human; Acetyl-Coenzyme A acetyltransferase 2 Human Recombinant; Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2; ACAT2 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: ACAT2 Human solution containing 20mM Tris pH-8, 0.1M NaCl, 1mM DTT and 20% glycerol.; Sterile Filtered clear solution.
• Concentration: 1mg/ml (varies by lot)
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNAG SDPVVIVSAA RTIIGSFNGA LAAVPVQDLG STVIKEVLKR ATVAPEDVSE VIFGHVLAAG CGQNPVRQAS VGAGIPYSVP AWSCQMICGS GLKAVCLAVQ SIGIGDSSIV VAGGMENMSK APHLAYLRTG VKIGEMPLTD SILCDGLTDA FHNCHMGITA ENVAKKWQVS REDQDKVAVL SQNRTENAQK AGHFDKEIVP VLVSTRKGLI EVKTDEFPRH GSNIEAMSKL KPYFLTDGTG TVTPANASGI NDGAAAVVLM KKSEADKRGL TPLARIVSWS QVGVEPSIMG IGPIPAIKQA VTKAGWSLED VDIFEINEAF AAVSAAIVKE LGLNPEKVNI EGGAIALGHP LGASGCRILV TLLHTLERMG RSRGVAALCI GGGMGIAMCV QR
• Sequence Length: 397

• Preparation and Storage: ACAT2 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for ACAT2 recombinant protein

Description: ACAT2 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-397 a.a.) and having a molecular mass of 45.4 kDa. The ACAT2 is fused to 36 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: ACAT2 enzyme participates in lipid metabolism. ACAT2 takes part in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. ACAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. ACAT2 deficiency contributes to severe mental retardation and hypotonus.

Product Categories/Family for ACAT2 recombinant protein

Enzymes; Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 148539872
• NCBI GeneID: 39
• NCBI Accession #: NP_005882.2
• NCBI GenBank Nucleotide #: NM_005891.2
• UniProt Accession #: Q9BWD1; Q16146; Q5TCL7; Q8TDM4; B7Z233; E1P5B1
• Molecular Weight: 44,643 Da
• NCBI Official Full Name: acetyl-CoA acetyltransferase, cytosolic isoform 1
• NCBI Official Synonym Full Names: acetyl-CoA acetyltransferase 2
• NCBI Official Symbol: ACAT2
• NCBI Protein Information: acetyl-CoA acetyltransferase, cytosolic; acetoacetyl Coenzyme A thiolase; acetyl-CoA transferase-like protein; cytosolic acetoacetyl-CoA thiolase
• UniProt Protein Name: Acetyl-CoA acetyltransferase, cytosolic
• Protein Family: Acetyl-CoA acetyltransferase
• UniProt Gene Name: ACAT2
• UniProt Synonym Gene Names: ACTL
• UniProt Entry Name: THIC_HUMAN

NCBI Description

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - tryptophan; Acetyltransferase; EC 2.3.1.9; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency