Mouse ATP-binding cassette, sub-family C (CFTR/MRP) , member 1 ELISA Kit | ABCC1 elisa kit
Mouse Multidrug resistance-associated protein 1, ABCC1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Uniprot Description
ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family
Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; cytoplasm; integral to membrane; plasma membrane
Molecular Function: lipid-transporting ATPase activity; hydrolase activity; transporter activity; ATPase activity; nucleotide binding; long-chain fatty acid transporter activity; sphingolipid transporter activity; glutathione S-conjugate-exporting ATPase activity; xenobiotic-transporting ATPase activity; efflux transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of substances; drug transporter activity; ATP binding
Biological Process: daunorubicin transport; response to drug; phospholipid efflux; transport; drug export; xenobiotic transport; multidrug transport; response to oxidative stress; transmembrane transport; plasma membrane long-chain fatty acid transport; positive regulation of cell migration
Research Articles on ABCC1
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Product Notes
The Mouse ABCC1 abcc1 (Catalog #AAA9327817) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327817 ELISA Kit recognizes Mouse ABCC1. It is sometimes possible for the material contained within the vial of "ATP-binding cassette, sub-family C (CFTR/MRP) , member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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