Mouse ATP-binding cassette sub-family A member 7 ELISA Kit | Abca7 elisa kit

Mouse ATP-binding cassette sub-family A member 7 ELISA Kit

Cat. Num. AAA2884133

• Gene Names: Abca7; ABCX; Abc51
• Reactivity: Mouse
• Synonyms: ATP-binding cassette sub-family A member 7; Mouse ATP-binding cassette sub-family A member 7 ELISA Kit; Abca7; Abca7 elisa kit

• Reactivity: Mouse
• Sequence Length: 2159

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.085 ng/mL
• Intra-Assay CV: <=6.3%
• Inter-Assay CV: <=8.5%
• Recovery: 97%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 15451840
• NCBI GeneID: 27403
• NCBI Accession #: NP_038878.1
• NCBI GenBank Nucleotide #: NM_013850.1
• UniProt Accession #: Q91V24; Q9JL36
• Molecular Weight: 236,884 Da
• NCBI Official Full Name: ATP-binding cassette sub-family A member 7
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family A (ABC1), member 7
• NCBI Official Symbol: Abca7
• NCBI Official Synonym Symbols: ABCX; Abc51
• NCBI Protein Information: ATP-binding cassette sub-family A member 7
• UniProt Protein Name: ATP-binding cassette sub-family A member 7
• Protein Family: ABC transporter A family
• UniProt Gene Name: Abca7
• UniProt Entry Name: ABCA7_MOUSE

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; cell junction; cell surface; endosome; Golgi apparatus; integral to membrane; intracellular; intracellular membrane-bound organelle; membrane; phagocytic cup; plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding; phospholipid transporter activity; protein binding; transporter activity

Biological Process: cholesterol efflux; memory; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of ATPase activity; peptide cross-linking; phagocytosis; phospholipid efflux; phospholipid scrambling; positive regulation of ATPase activity; positive regulation of phagocytosis; transport