Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Protein tyrosine phosphatase type IVA 1 (PTP4A1) Standard Curve.)
Rat Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit | PTP4A1 elisa kit
Rat Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Protein tyrosine phosphatase type IVA 1 (PTP4A1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Protein tyrosine phosphatase type IVA 1 (PTP4A1) Standard Curve.)
Background: Protein tyrosine phosphatase type IVA 1 is an enzyme belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.
NCBI and Uniprot Product Information
Uniprot Description
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues
By similarity.
Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Enzyme regulation: Inhibited by sodium orthovanadate and pentamidine. Ref.1
Subunit structure: Homotrimer. Interacts with ATF5 and tubulin
By similarity.
Subcellular location: Cell membrane
By similarity. Early endosome
By similarity. Endoplasmic reticulum
By similarity. Cytoplasm
By similarity. Cytoplasm › cytoskeleton › spindle
By similarity. Note: And mitotic spindle
By similarity. Ref.1
Tissue specificity: Brain (neurons and oligodendrocytes), skeletal muscle, regenerating liver, tumor cell lines. Expressed in enterocytes of the small intestine villi and colonic surface, zymogen cells of the stomach, proximal tubule cells of the kidney, bronchiolar epithelium, but not in esophagus and heart (at protein level). Ref.1 Ref.4 Ref.5
Developmental stage: Expressed in fetal brain. Up-regulated during oligodendroglial differentiation. Expressed in the developing intestine, esophagus, liver, kidney and lung (at protein level). Ref.4 Ref.5 Ref.6
Induction: By hepatectomy, mitogens, and ischemia-reperfusion. Ref.1
Post-translational modification: Farnesylated. Farnesylation is required for membrane targeting
By similarity.
Sequence similarities: Belongs to the protein-tyrosine phosphatase family.Contains 1 tyrosine-protein phosphatase domain.
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Product Notes
The Rat PTP4A1 ptp4a1 (Catalog #AAA9712019) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9712019 ELISA Kit recognizes Rat PTP4A1. It is sometimes possible for the material contained within the vial of "Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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