Human Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit | PTP4A1 elisa kit

Human Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit

Cat. Num. AAA9714722

• Gene Names: PTP4A1; HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
• Reactivity: Human
• Synonyms: Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1); Human Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit; PTP4A1; RP5-1148A21.2; DKFZp779M0721; HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1; Protein tyrosine phosphatase IVA1; protein tyrosine phosphatase type IVA protein 1; PTP4A1 elisa kit

• Reactivity: Human
• Specificity: Human Protein tyrosine phosphatase type IVA 1 (PTP4A1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PTP4A1. No significant cross-reactivity or interference between Human PTP4A1 and analogues was observed.
• Sequence Length: 173

• Assay Type: Sandwich
• Preparation and Storage: Store at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PTP4A1 elisa kit

Principle of the Assay: Human Protein Tyrosine Phosphatase Type IVA 1 (PTP4A1) ELISA Kit employs a two-site sandwich ELISA to quantitate PTP4A1 in samples. An antibody specific for PTP4A1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any PTP4A1 present is bound by the immobilized antibody. After removing any unbound substances, HRP-Conjugated Human PTP4A1 detection antibody is added to the wells. Following a wash to remove any unbound HRP reagent, a Chromogen solution is added to the wells and color develops in proportion to the amount of PTP4A1 bound in the initial step. The color development is stopped and the intensity of the color is measured.!!Background/Introduction: Protein tyrosine phosphatase type IVA 1 is an enzyme belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane.The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 4506283
• NCBI GeneID: 7803
• NCBI Accession #: NP_003454.1
• NCBI GenBank Nucleotide #: NP_003454.1
• UniProt Accession #: Q93096
• NCBI Official Full Name: protein tyrosine phosphatase type IVA 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase 4A1
• NCBI Official Symbol: PTP4A1
• NCBI Official Synonym Symbols: HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
• NCBI Protein Information: protein tyrosine phosphatase type IVA 1
• UniProt Protein Name: Protein tyrosine phosphatase type IVA 1
• Protein Family: Protein tyrosine phosphatase
• UniProt Gene Name: PTP4A1
• UniProt Synonym Gene Names: PRL1; PTPCAAX1; PRL-1
• UniProt Entry Name: TP4A1_HUMAN

NCBI Description

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Uniprot Description

PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q12

Cellular Component: internal side of plasma membrane; endoplasmic reticulum; early endosome; cytoplasm; spindle

Molecular Function: protein tyrosine phosphatase activity

Biological Process: multicellular organismal development; cell cycle; positive regulation of cell migration