6-phosphofructokinase, liver type (PFKL) Recombinant Protein | PFKL recombinant protein

Recombinant Human 6-phosphofructokinase, liver type (PFKL)

Cat. Num. AAA964737

• Gene Names: PFKL; PFK-B; PFK-L; ATP-PFK
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 6-phosphofructokinase; liver type (PFKL); Recombinant Human 6-phosphofructokinase; PFKL recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-780, Full length protein
• Sequence: AAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
• Sequence Length: 779

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PFKL recombinant protein

Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. This protein represents the L subunit. Alternate splicing results in two transcript variants, one of which is a candidate for nonsense-mediated decay (NMD).

NCBI and Uniprot Product Information

• NCBI GI #: 590122057
• NCBI GeneID: 5211
• NCBI Accession #: NP_001002021.2
• NCBI GenBank Nucleotide #: NM_001002021.2
• UniProt Accession #: P17858; Q96A64; Q96IH4; Q9BR91
• Molecular Weight: 90,203 Da
• NCBI Official Full Name: ATP-dependent 6-phosphofructokinase, liver type isoform a
• NCBI Official Synonym Full Names: phosphofructokinase, liver type
• NCBI Official Symbol: PFKL
• NCBI Official Synonym Symbols: PFK-B; PFK-L; ATP-PFK
• NCBI Protein Information: ATP-dependent 6-phosphofructokinase, liver type
• UniProt Protein Name: ATP-dependent 6-phosphofructokinase, liver type
• Protein Family: ATP-dependent 6-phosphofructokinase
• UniProt Gene Name: PFKL
• UniProt Synonym Gene Names: ATP-PFK; PFK-L

NCBI Description

This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.