Rabbit GALNT7 Polyclonal Antibody | anti-GALNT7 antibody

GALNT7 Antibody

Cat. Num. AAA9630543

• Gene Names: GALNT7; GalNAcT7; GALNAC-T7
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: GALNT7; Polyclonal Antibody; GALNT7 Antibody; GalNAc T7; GalNAc-T7; GalNAcT7; GALNT 7; Galnt7; GALT7_HUMAN; N acetylgalactosaminyltransferase 7; N-acetylgalactosaminyltransferase 7; Polypeptide GalNAc transferase 7; Polypeptide N acetylgalactosaminyltransferase 7; pp GaNTase 7; pp-GaNTase 7; Protein UDP acetylgalactosaminyltransferase 7; Protein-UDP acetylgalactosaminyltransferase 7; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 7; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; anti-GALNT7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: GALNT7 Antibody detects endogenous levels of GALNT7.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GALNT7 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human GALNT7.
• Conjugation: Unconjugated
• Similarity: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
• Tissue Specificity: Widely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS.
• Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-GALNT7 antibody

Golgi apparatus membrane; Single-pass type II membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 157502212
• NCBI GeneID: 51809
• NCBI Accession #: NP_059119.2
• NCBI GenBank Nucleotide #: NM_017423.2
• UniProt Accession #: Q86SF2; Q7Z5W7; Q9UJ28; B3KQU3
• Molecular Weight: 75,389 Da
• NCBI Official Full Name: N-acetylgalactosaminyltransferase 7
• NCBI Official Synonym Full Names: polypeptide N-acetylgalactosaminyltransferase 7
• NCBI Official Symbol: GALNT7
• NCBI Official Synonym Symbols: GalNAcT7; GALNAC-T7
• NCBI Protein Information: N-acetylgalactosaminyltransferase 7; pp-GaNTase 7; polypeptide GalNAc transferase 7; protein-UDP acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactos
• UniProt Protein Name: N-acetylgalactosaminyltransferase 7
• Protein Family: N-acetylgalactosaminyltransferase
• UniProt Gene Name: GALNT7
• UniProt Synonym Gene Names: GalNAc-T7; pp-GaNTase 7
• UniProt Entry Name: GALT7_HUMAN

NCBI Description

This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]

Uniprot Description

GALNT7: a glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties.

Protein type: EC 2.4.1.-; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.1

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity; carbohydrate binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; carbohydrate metabolic process; post-translational protein modification