Rabbit THBS4 Polyclonal Antibody | anti-THBS4 antibody

THBS4 Antibody

Cat. Num. AAA9630366

• Gene Names: THBS4; TSP4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: THBS4; Polyclonal Antibody; THBS4 Antibody; Thbs4; thrombospondin 4; thrombospondin 4b; Thrombospondin IV; Thrombospondin-4; TSP4; TSP4_HUMAN; anti-THBS4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: THBS4 Antibody detects endogenous levels of THBS4.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-THBS4 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human THBS4.
• Conjugation: Unconjugated
• Similarity: Belongs to the thrombospondin family.
• Subunit Structure: Homopentamer; disulfide-linked. Interacts with PTBP3. Interacts with NOTCH1 (By similarity). Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation.
• Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-THBS4 antibody

Endoplasmic reticulum; Sarcoplasmic reticulum; Secreted; Extracellular space; Extracellular matrix; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 31543806
• NCBI GeneID: 7060
• NCBI Accession #: NP_003239
• NCBI GenBank Nucleotide #: NM_003248.4
• UniProt Accession #: P35443; Q86TG2; B2R909
• Molecular Weight: 105,869 Da
• NCBI Official Full Name: thrombospondin-4
• NCBI Official Synonym Full Names: thrombospondin 4
• NCBI Official Symbol: THBS4
• NCBI Official Synonym Symbols: TSP4
• NCBI Protein Information: thrombospondin-4
• UniProt Protein Name: Thrombospondin-4
• Protein Family: Thrombospondin
• UniProt Gene Name: THBS4
• UniProt Synonym Gene Names: TSP4
• UniProt Entry Name: TSP4_HUMAN

NCBI Description

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [provided by RefSeq, Jul 2008]

Uniprot Description

THBS4: Acts as an extracellular mitogen and stimulates early erythroid progenitors proliferation in presence of EPO. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Belongs to the thrombospondin family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: extracellular matrix; extracellular space; sarcoplasmic reticulum; endoplasmic reticulum; extracellular region; basement membrane

Molecular Function: heparin binding; integrin binding; protein binding; growth factor activity; calcium ion binding

Biological Process: behavioral response to pain; negative regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division; tissue remodeling; myoblast migration; positive regulation of endothelial cell proliferation; response to unfolded protein; regulation of tissue remodeling