Rabbit anti-Human ELOVL7 Polyclonal Antibody | anti-ELOVL7 antibody

ELOVL7 Antibody

Cat. Num. AAA9630276

• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ELOVL7; Polyclonal Antibody; ELOVL7 Antibody; 3-keto acyl-CoA synthase Elovl7; Elongation of very long chain fatty acids protein 7; ELOV7_HUMAN; ELOVL family member 7 elongation of long chain fatty acids; ELOVL family member 7 elongation of long chain fatty acids yeast; ELOVL fatty acid elongase 7; anti-ELOVL7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ELOVL7 Antibody detects endogenous levels of ELOVL7.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ELOVL7 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ELOVL7.
• Conjugation: Unconjugated
• Similarity: The C-terminal di-lysine motif may confer endoplasmic reticulum localization. Belongs to the ELO family. ELOVL7 subfamily.
• Tissue Specificity: Expressed in most tissues except heart and skeletal muscle.
• Function: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ELOVL7 antibody

Endoplasmic reticulum membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 157388949
• NCBI GeneID: 79993
• NCBI Accession #: NP_001098028
• NCBI GenBank Nucleotide #: NM_001104558.1
• UniProt Accession #: A1L3X0; Q589T3; Q9H5D0; Q9NT66
• Molecular Weight: 33,356 Da
• NCBI Official Full Name: elongation of very long chain fatty acids protein 7 isoform 1
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 7
• NCBI Official Symbol: ELOVL7
• NCBI Protein Information: elongation of very long chain fatty acids protein 7; ELOVL FA elongase 7; 3-keto acyl-CoA synthase ELOVL7; very-long-chain 3-oxoacyl-CoA synthase 7; ELOVL family member 7, elongation of long chain fatty acids
• UniProt Protein Name: Elongation of very long chain fatty acids protein 7
• Protein Family: Elongation of very long chain fatty acids protein
• UniProt Gene Name: ELOVL7
• UniProt Synonym Gene Names: ELOVL FA elongase 7
• UniProt Entry Name: ELOV7_HUMAN

Uniprot Description

ELOVL7: Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. Belongs to the ELO family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 2.3.1.199

Chromosomal Location of Human Ortholog: 5q12.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: transferase activity; protein binding

Biological Process: very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; fatty acid elongation, saturated fatty acid; cellular lipid metabolic process