Rabbit anti-Human SLC5A8 Polyclonal Antibody | anti-SLC5A8 antibody

SLC5A8 Antibody

Cat. Num. AAA9630175

• Gene Names: SLC5A8; AIT; SMCT; SMCT1
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SLC5A8; Polyclonal Antibody; SLC5A8 Antibody; AIT; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; MGC125354; SC5A8_HUMAN; SMCT; SMCT1; sodium coupled monocarboxylate transporter 1; Sodium iodide related cotransporter; Sodium iodide-related cotransporter; Sodium-coupled monocarboxylate transporter 1; solute carrier family 5 iodide transporter member 8; Solute carrier family 5 member 8; anti-SLC5A8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SLC5A8 Antibody detects endogenous levels of SLC5A8.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SLC5A8 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human SLC5A8.
• Conjugation: Unconjugated
• Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family.
• Tissue Specificity: Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.
• Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
• Note: Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SLC5A8 antibody

Apical cell membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 296452898
• NCBI GeneID: 160728
• UniProt Accession #: Q8N695; Q2TB99; Q7Z2H9
• Molecular Weight: 110.0
• NCBI Official Full Name: Sodium-coupled monocarboxylate transporter 1
• NCBI Official Synonym Full Names: solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
• NCBI Official Symbol: SLC5A8
• NCBI Official Synonym Symbols: AIT; SMCT; SMCT1
• NCBI Protein Information: sodium-coupled monocarboxylate transporter 1; apical iodide transporter; solute carrier family 5 member 8; sodium iodide-related cotransporter; electrogenic sodium monocarboxylate cotransporter; solute carrier family 5 (iodide transporter), member 8
• UniProt Protein Name: Sodium-coupled monocarboxylate transporter 1
• Protein Family: Sodium-coupled monocarboxylate transporter
• UniProt Gene Name: SLC5A8
• UniProt Synonym Gene Names: AIT; SMCT; SMCT1
• UniProt Entry Name: SC5A8_HUMAN

NCBI Description

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

Uniprot Description

SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral; Tumor suppressor; Apoptosis

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: symporter activity

Biological Process: apoptosis; sodium ion transport; ion transport; transmembrane transport