Rabbit anti-Human ATP13A2 Polyclonal Antibody | anti-ATP13A2 antibody

ATP13A2 Antibody

Cat. Num. AAA9629850

• Gene Names: ATP13A2; CLN12; KRPPD; PARK9; SPG78; HSA9947
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ATP13A2; Polyclonal Antibody; ATP13A2 Antibody; AT132_HUMAN; Atp13a2; ATPase type 13A2; CLN12; FLJ26510; HSA9947; KRPPD; PARK9; Probable cation transporting ATPase 13A2; Probable cation-transporting ATPase 13A2; Putative ATPase; RP1-37C10.4; anti-ATP13A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ATP13A2 Antibody detects endogenous levels of ATP13A2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ATP13A2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ATP13A2.
• Conjugation: Unconjugated
• Similarity: Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type V subfamily.
• Post Translational Modifications: Autophosphorylated.
• Subunit Structure: Interacts with MYCBP2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2.
• Tissue Specificity: Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level).
• Function: ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ATP13A2 antibody

Membrane; Multi-pass membrane protein; Lysosome; Lysosome membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 213972619
• NCBI GeneID: 23400
• NCBI Accession #: NP_001135445.1
• NCBI GenBank Nucleotide #: NM_001141973.2
• UniProt Accession #: Q9NQ11; O75700; Q5JXY1; Q5JXY2; Q6S9Z9
• Molecular Weight: 128,323 Da
• NCBI Official Full Name: cation-transporting ATPase 13A2 isoform 2
• NCBI Official Synonym Full Names: ATPase 13A2
• NCBI Official Symbol: ATP13A2
• NCBI Official Synonym Symbols: CLN12; KRPPD; PARK9; SPG78; HSA9947
• NCBI Protein Information: cation-transporting ATPase 13A2; probable cation-transporting ATPase 13A2
• UniProt Protein Name: Cation-transporting ATPase 13A2
• Protein Family: Probable cation-transporting ATPase
• UniProt Gene Name: ATP13A2

NCBI Description

This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]

Uniprot Description

ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.3.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: autophagic vacuole; cell soma; integral component of membrane; integral component of plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle; vesicle membrane

Molecular Function: ATP binding; ATPase activity; calcium-transporting ATPase activity; cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding

Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of intracellular protein transport; regulation of macroautophagy; zinc ion homeostasis

Disease: Kufor-rakeb Syndrome; Spastic Paraplegia 78, Autosomal Recessive