Rabbit anti-Human DKKL1 Polyclonal Antibody | anti-DKKL1 antibody
DKKL1 Antibody
Gene Names
DKKL1; SGY; CT34; SGY1; SGY-1
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
DKKL1; Polyclonal Antibody; DKKL1 Antibody; Cancer/testis antigen 34; CT34; dickkopf like 1; Dickkopf-like protein 1; DKKL1_HUMAN; Protein soggy-1; SGY; SGY-1; SGY1; soggy 1; anti-DKKL1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
DKKL1 Antibody detects endogenous levels of DKKL1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-DKKL1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human DKKL1.
Conjugation
Unconjugated
Similarity
Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Post Translational Modifications
N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.
Subunit Structure
Interacts with SLXL1; Co-localize in seminiferous tubules. Interacts with SLY.
Tissue Specificity
More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Note
Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-DKKL1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,007 Da
NCBI Official Full Name
dickkopf-like protein 1 isoform 2
NCBI Official Synonym Full Names
dickkopf like acrosomal protein 1
NCBI Official Symbol
DKKL1
NCBI Official Synonym Symbols
SGY; CT34; SGY1; SGY-1
NCBI Protein Information
dickkopf-like protein 1
UniProt Protein Name
Dickkopf-like protein 1
Protein Family
UniProt Gene Name
DKKL1
UniProt Synonym Gene Names
CT34; SGY-1
NCBI Description
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Description
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Research Articles on DKKL1
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Product Notes
The DKKL1 dkkl1 (Catalog #AAA9629841) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DKKL1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DKKL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the DKKL1 dkkl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DKKL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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