Rabbit SH3PXD2B Polyclonal Antibody | anti-SH3PXD2B antibody

SH3PXD2B Antibody

Cat. Num. AAA9629183

• Gene Names: SH3PXD2B; FTHS; HOFI; TKS4; TSK4; FAD49; FLJ20831; KIAA1295
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SH3PXD2B; Polyclonal Antibody; SH3PXD2B Antibody; Adapter protein HOFI; Factor for adipocyte differentiation 49; FAD49; FLJ20831; FTHS; KIAA1295; SH3 and PX domain-containing protein 2B; SPD2B_HUMAN; TKS4; Tyrosine kinase substrate with four SH3 domains; anti-SH3PXD2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SH3PXD2B Antibody detects endogenous levels of total SH3PXD2B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SH3PXD2B antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3, 4-bisphosphate (PtdIns(3, 4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3, 5-bisphosphate (PtdIns(3, 5)P2). Binds to the third intramolecular SH3 domain (By similarity). Belongs to the SH3PXD2 family.
• Post Translational Modifications: Phosphorylated in SRC-transformed cells.
• Subunit Structure: Interacts with ADAM15 (By similarity). Interacts with NOXO1. Interacts (via SH3 domains) with NOXA1; the interaction is direct. Interacts with FASLG.
• Tissue Specificity: Expressed in fibroblasts.
• Function: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).
• Note: Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SH3PXD2B antibody

Cytoplasm; Cell projection; Podosome; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 63055059
• NCBI GeneID: 285590
• NCBI Accession #: NP_001017995.1
• NCBI GenBank Nucleotide #: NM_001017995.2
• UniProt Accession #: A1X283; Q9P2Q1; B6F0V2; Q9NWI5
• Molecular Weight: 101,579 Da
• NCBI Official Full Name: SH3 and PX domain-containing protein 2B
• NCBI Official Synonym Full Names: SH3 and PX domains 2B
• NCBI Official Symbol: SH3PXD2B
• NCBI Official Synonym Symbols: FTHS; HOFI; TKS4; TSK4; FAD49; FLJ20831; KIAA1295
• NCBI Protein Information: SH3 and PX domain-containing protein 2B; OTTHUMP00000223471; OTTHUMP00000223472; adapter protein HOFI; adaptor protein HOFI; factor for adipocyte differentiation 49; tyrosine kinase substrate with four SH3 domains
• UniProt Protein Name: SH3 and PX domain-containing protein 2B
• Protein Family: SH3 and PX domain-containing protein
• UniProt Gene Name: SH3PXD2B
• UniProt Synonym Gene Names: FAD49; KIAA1295; TKS4
• UniProt Entry Name: SPD2B_HUMAN

NCBI Description

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome. [provided by RefSeq]

Uniprot Description

SH3PXD2B: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS). It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers. Belongs to the SH3PXD2 family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cell projection; cytoplasm; podosome; cell junction

Molecular Function: protein binding; phosphatidylinositol-5-phosphate binding; SH2 domain binding; phosphatidylinositol 3-phosphate binding

Biological Process: extracellular matrix disassembly; eye development; heart development; superoxide metabolic process; positive regulation of fat cell differentiation; cell differentiation; skeletal development

Disease: Frank-ter Haar Syndrome