MSRA blocking peptide

MSRA Blocking Peptide

Cat. Num. AAA9621860

• Gene Names: MSRA; PMSR
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: MSRA; MSRA Blocking Peptide; Cytosolic methionine S sulfoxide reductase; Methionine sulphoxide reductase A; mitochondrial peptide methionine sulfoxide reductase; MSR A; msrA; MSRA_HUMAN; peptide met (O) reductase; Peptide Met(O) reductase; Peptide methionine (S) S oxide reductase; Peptide-methionine (S)-S-oxide reductase; PMSR; Protein methionine S oxide reductase; Protein-methionine-S-oxide reductase; MSRA blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for MSRA blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MSRA blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 208609993
• NCBI GeneID: 4482
• NCBI Accession #: NP_001129142.1
• NCBI GenBank Nucleotide #: NP_001129142.1
• UniProt Accession #: Q9UJ68; Q52TC4; Q549N4; Q66MI7; E9PAS8
• Molecular Weight: 23,627 Da
• NCBI Official Full Name: mitochondrial peptide methionine sulfoxide reductase isoform b
• NCBI Official Synonym Full Names: methionine sulfoxide reductase A
• NCBI Official Symbol: MSRA
• NCBI Official Synonym Symbols: PMSR
• NCBI Protein Information: mitochondrial peptide methionine sulfoxide reductase; cytosolic methionine-S-sulfoxide reductase; peptide Met(O) reductase; peptide met (O) reductase; peptide-methionine (S)-S-oxide reductase
• UniProt Protein Name: Mitochondrial peptide methionine sulfoxide reductase
• Protein Family: Mitochondrial peptide methionine sulfoxide reductase
• UniProt Gene Name: MSRA
• UniProt Synonym Gene Names: Peptide Met(O) reductase; PMSR
• UniProt Entry Name: MSRA_HUMAN

NCBI Description

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

MSRA: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: EC 1.8.4.11; Oxidoreductase

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: nucleoplasm; mitochondrion; membrane; cytoplasm; actin cytoskeleton

Molecular Function: peptide-methionine-(S)-S-oxide reductase activity

Biological Process: protein repair; protein modification process; methionine metabolic process; response to oxidative stress