Oligophrenin 1 Blocking Peptide | OPHN1 blocking peptide

Oligophrenin 1 Blocking Peptide

Cat. Num. AAA9621139

• Gene Names: OPHN1; OPN1; MRX60; ARHGAP41
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Oligophrenin 1; Oligophrenin 1 Blocking Peptide; ARHGAP41; Mental retardation; X linked 60; MRX60; Rho GTPase activating protein; OPN1; OPHN1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for OPHN1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for OPHN1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4505507
• NCBI GeneID: 4983
• NCBI Accession #: NP_002538.1
• NCBI GenBank Nucleotide #: NM_002547.2
• UniProt Accession #: O60890; Q5JQ81; Q6PCC1; Q8WX47; B9EIP8
• Molecular Weight: 91,641 Da
• NCBI Official Full Name: oligophrenin-1
• NCBI Official Synonym Full Names: oligophrenin 1
• NCBI Official Symbol: OPHN1
• NCBI Official Synonym Symbols: OPN1; MRX60; ARHGAP41
• NCBI Protein Information: oligophrenin-1; mental retardation, X-linked 60; oligophrenin-1, Rho-GTPase activating protein
• UniProt Protein Name: Oligophrenin-1
• Protein Family: Oligophrenin
• UniProt Gene Name: OPHN1
• UniProt Entry Name: OPHN1_HUMAN

Uniprot Description

OPHN1: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Defects in OPHN1 are the cause of mental retardation X- linked OPHN1-related (MRXSO); formerly designated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated with cerebellar hypoplasia and distinctive facial dysmorphism.

Protein type: Motility/polarity/chemotaxis; GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: dendritic spine; terminal button; cell junction; cytosol; actin cytoskeleton

Molecular Function: ionotropic glutamate receptor binding; phospholipid binding; actin binding

Biological Process: nervous system development; axon guidance; regulation of small GTPase mediated signal transduction; regulation of synaptic transmission, glutamatergic; small GTPase mediated signal transduction; synaptic vesicle endocytosis; regulation of endocytosis; actin cytoskeleton organization and biogenesis; signal transduction; substrate-bound cell migration, cell extension

Disease: Mental Retardation, X-linked, With Cerebellar Hypoplasia And Distinctive Facial Appearance