CHCHD3 blocking peptide

CHCHD3 Blocking Peptide

Cat. Num. AAA9620959

• Gene Names: CHCHD3; Mic19; MINOS3; PPP1R22
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: CHCHD3; CHCHD3 Blocking Peptide; CHCH3_HUMAN; CHCHD 3; Chchd3; Coiled coil helix coiled coil helix domain containing 3; Coiled coil helix coiled coil helix domain containing protein 3 mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3; FLJ20420; MINOS3; mitochondrial; Mitochondrial inner membrane organizing system 3; PPP1R22; Protein phosphatase 1 regulatory subunit 22; CHCHD3 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for CHCHD3 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHCHD3 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 953768340
• NCBI GeneID: 54927
• NCBI Accession #: NP_001304106.1
• NCBI GenBank Nucleotide #: NM_001317177.1
• UniProt Accession #: Q9NX63
• Molecular Weight: Predicted MW: 26kDa
• NCBI Official Full Name: MICOS complex subunit MIC19 isoform 1
• NCBI Official Synonym Full Names: coiled-coil-helix-coiled-coil-helix domain containing 3
• NCBI Official Symbol: CHCHD3
• NCBI Official Synonym Symbols: Mic19; MINOS3; PPP1R22
• NCBI Protein Information: MICOS complex subunit MIC19
• UniProt Protein Name: MICOS complex subunit MIC19
• UniProt Gene Name: CHCHD3
• UniProt Synonym Gene Names: MIC19; MINOS3
• UniProt Entry Name: MIC19_HUMAN

NCBI Description

The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

CHCHD3: May be a scaffolding protein that stabilizes protein complexes involved in maintaining mitochondrial crista architecture and protein import.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: mitochondrion; cytoplasm; mitochondrial inner membrane; nucleus

Molecular Function: protein binding; protein complex scaffold; phosphatase binding

Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrial fusion; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter