TSH3 blocking peptide

TSH3 Blocking Peptide

Cat. Num. AAA9620388

• Gene Names: TSHZ3; TSH3; ZNF537
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: TSH3; TSH3 Blocking Peptide; KIAA1474; Teashirt homolog 3; TSH3_HUMAN; TSHZ3; Zinc finger protein 537; TSH3 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for TSH3 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TSH3 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 127138957
• NCBI GeneID: 57616
• NCBI Accession #: NP_065907.2
• NCBI GenBank Nucleotide #: NM_020856.3
• UniProt Accession #: Q63HK5; Q9H0G6; Q9P254; A1L0U7
• Molecular Weight: 118,566 Da
• NCBI Official Full Name: teashirt homolog 3
• NCBI Official Synonym Full Names: teashirt zinc finger homeobox 3
• NCBI Official Symbol: TSHZ3
• NCBI Official Synonym Symbols: TSH3; ZNF537
• NCBI Protein Information: teashirt homolog 3; teashirt 3; zinc finger protein 537; teashirt family zinc finger 3
• UniProt Protein Name: Teashirt homolog 3
• UniProt Gene Name: TSHZ3
• UniProt Synonym Gene Names: KIAA1474; TSH3; ZNF537
• UniProt Entry Name: TSH3_HUMAN

Uniprot Description

TSHZ3: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Belongs to the teashirt C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: nucleoplasm; growth cone; mitochondrion; nucleus

Molecular Function: protein binding; DNA binding; metal ion binding; chromatin binding

Biological Process: transcription, DNA-dependent; sensory perception of touch; in utero embryonic development; ureteric bud development; positive regulation of smooth muscle cell differentiation; neurological control of breathing; musculoskeletal movement; negative regulation of transcription, DNA-dependent; metanephros development; lung development