Testing Data
(Western blot detection of TXNRD2 in A431,U251, U2OS,LNCAP&Hela cell lysates and using TXNRD2 antibody (1:1000 diluted). Predicted band size: 56KDa Observed band size: 56KDa.)
Mouse anti-Human TXNRD2 Monoclonal Antibody | anti-TXNRD2 antibody
TXNRD2 Antibody
Testing Data
(Western blot detection of TXNRD2 in A431,U251, U2OS,LNCAP&Hela cell lysates and using TXNRD2 antibody (1:1000 diluted). Predicted band size: 56KDa Observed band size: 56KDa.)
Testing Data
(Western blot detection of TXNRD2 in A431,U251, U2OS,LNCAP&Hela cell lysates and using TXNRD2 antibody (1:1000 diluted). Predicted band size: 56KDa Observed band size: 56KDa.)
Entrez Summary: Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Uniprot Description
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.MiscellaneousThe active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity ().
Research Articles on TXNRD2
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Product Notes
The TXNRD2 txnrd2 (Catalog #AAA857917) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TXNRD2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TXNRD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TXNRD2 txnrd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TXNRD2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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