Rabbit SETBP1 Polyclonal Antibody | anti-SETBP1 antibody

SETBP1 Antibody

Cat. Num. AAA9611487

• Gene Names: SETBP1; SEB; MRD29
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SETBP1; Polyclonal Antibody; SETBP1 Antibody; SEB; SET binding protein 1; SET-binding protein; SETBP 1; SETBP_HUMAN; Setbp1; anti-SETBP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SETBP1 Antibody detects endogenous levels of SETBP1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 242

• Applicable Applications for anti-SETBP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human SETBP1.
• Tissue Specificity: Expressed in numerous tissues. Expressed at low levels in myeloid and monocytic cells as well as in CD34+ cells; expression levels are higher in myeloid malignancies.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Nucleus
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, using SETBP1 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-SETBP1 antibody

Interacts with SET.

NCBI and Uniprot Product Information

• NCBI GI #: 194294556
• NCBI GeneID: 26040
• NCBI Accession #: NP_001123582.1
• NCBI GenBank Nucleotide #: NP_001123582.1
• UniProt Accession #: Q9Y6X0
• Molecular Weight: Observed: 150 kDa; Predicted: 176 kDa
• NCBI Official Full Name: SET-binding protein isoform b
• NCBI Official Synonym Full Names: SET binding protein 1
• NCBI Official Symbol: SETBP1
• NCBI Official Synonym Symbols: SEB; MRD29
• NCBI Protein Information: SET-binding protein
• UniProt Protein Name: SET-binding protein
• Protein Family: SET-binding protein
• UniProt Gene Name: SETBP1
• UniProt Synonym Gene Names: KIAA0437; SEB

NCBI Description

This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

SETBP1: Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 18q12.3

Molecular Function: protein binding

Disease: Mental Retardation, Autosomal Dominant 29; Schinzel-giedion Midface Retraction Syndrome