Rabbit anti-Human, Rat SETBP1 Polyclonal Antibody | anti-SETBP1 antibody

SETBP1 Polyclonal Antibody

Cat. Num. AAA9433991

• Gene Names: SETBP1; SEB; MRD29
• Reactivity: Human, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity purification
• Synonyms: SETBP1; Polyclonal Antibody; SETBP1 Polyclonal Antibody; MRD29; SEB; SET-binding protein; anti-SETBP1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-SETBP1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:100
• Immunogen: Recombinant fusion protein of human SETBP1 (NP_001123582.1).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using SETBP1 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of A-549 cells using SETBP1 antibody.)

Related Product Information for anti-SETBP1 antibody

This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-SETBP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 194294556
• NCBI GeneID: 26040
• NCBI Accession #: NP_001123582.1
• NCBI GenBank Nucleotide #: NM_001130110.1
• UniProt Accession #: Q9Y6X0; Q6P6C3; Q9UEF3; A6H8W5
• Molecular Weight: 170 kDa
• NCBI Official Full Name: SET-binding protein isoform b
• NCBI Official Synonym Full Names: SET binding protein 1
• NCBI Official Symbol: SETBP1
• NCBI Official Synonym Symbols: SEB; MRD29
• NCBI Protein Information: SET-binding protein
• UniProt Protein Name: SET-binding protein
• Protein Family: SET-binding protein
• UniProt Gene Name: SETBP1
• UniProt Synonym Gene Names: KIAA0437; SEB

NCBI Description

This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

SETBP1: Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 18q12.3

Molecular Function: protein binding

Disease: Mental Retardation, Autosomal Dominant 29; Schinzel-giedion Midface Retraction Syndrome