Western Blot (WB)
(Western blot analysis of extracts from COLO 320 cells, using SDPR Antibody. The lane on the left was treated with blocking peptide.)
Rabbit SDPR Polyclonal Antibody | anti-SDPR antibody
SDPR Antibody
Gene Names
CAVIN2; SDR; SDPR; PS-p68; cavin-2
Reactivity
Human, Mouse, RatPredicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SDPR; Polyclonal Antibody; SDPR Antibody; Cavin 2; Cavin-2; Phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS p68; PS-p68; Sdpr; SDPR_HUMAN; SDR; Serum deprivation response; Serum deprivation response protein; Serum deprivation-response protein; anti-SDPR antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Clonality
Polyclonal
Isotype
IgG
Specificity
SDPR Antibody detects endogenous levels of SDPR.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
425
Applicable Applications for anti-SDPR antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human SDPR.
Tissue Specificity
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Cytosol
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from COLO 320 cells, using SDPR Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from COLO 320 cells, using SDPR Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-SDPR antibody
Description: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Post Translational Modifications: Phosphorylated on Ser residues.
Subunit Structure: Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).
Similarity: The leucine-zipper domain is essential for its localization in the caveolae. Belongs to the CAVIN family.
Post Translational Modifications: Phosphorylated on Ser residues.
Subunit Structure: Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).
Similarity: The leucine-zipper domain is essential for its localization in the caveolae. Belongs to the CAVIN family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 70 kDa
Predicted: 48 kDa
Predicted: 48 kDa
NCBI Official Full Name
caveolae-associated protein 2
NCBI Official Synonym Full Names
caveolae associated protein 2
NCBI Official Symbol
CAVIN2
NCBI Official Synonym Symbols
SDR; SDPR; PS-p68; cavin-2
NCBI Protein Information
caveolae-associated protein 2
UniProt Protein Name
Serum deprivation-response protein
Protein Family
UniProt Gene Name
SDPR
UniProt Entry Name
SDPR_HUMAN
NCBI Description
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Uniprot Description
SDPR: May play a role in targeting PRKCA to caveolae. Belongs to the PTRF/SDPR family.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 2q32-q33
Cellular Component: cytoplasm; caveola; cytosol
Molecular Function: protein binding; protein kinase C binding; phosphatidylserine binding; phospholipid binding
Research Articles on SDPR
Similar Products
Product Notes
The SDPR sdpr (Catalog #AAA9611484) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SDPR Antibody reacts with Human, Mouse, Rat Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's SDPR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the SDPR sdpr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SDPR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
