Rabbit anti-Human, Mouse LAB Polyclonal Antibody | anti-LAB antibody

LAB Antibody

Cat. Num. AAA9603213

• Gene Names: LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: LAB; Polyclonal Antibody; LAB Antibody; HSPC046; LAT2; Linker for activation of B cells; Linker for activation of B-cells; Linker for activation of T cells family member 2; Linker for activation of T cells transmembrane adaptor 2; Linker for activation of T-cells family member 2; Membrane associated adapter molecule; Membrane-associated adapter molecule; Non T cell activation linker; Non-T-cell activation linker; NTAL_HUMAN; WBSCR 5; Wbscr15; Williams Beuren syndrome chromosome region 15; Williams Beuren syndrome chromosome region 5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; WSCR5; anti-LAB antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LAB antibody detects endogenous levels of LAB
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 243

• Applicable Applications for anti-LAB antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human LAB
• Subcellular Location: Cell Membrane. Present in lipid rafts.
• Tissue Specificity: Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts of Human peripheral lymphocytes tissue sample, using LAB Antibody(MBS9603213).)

Related Product Information for anti-LAB antibody

Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Subunit Structure: When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
Post-translational Modifications: Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2. May be polyubiquitinated.

NCBI and Uniprot Product Information

• NCBI GI #: 14702182
• NCBI GeneID: 7462
• NCBI Accession #: NP_054865.2
• NCBI GenBank Nucleotide #: NM_014146.3
• UniProt Accession #: Q9GZY6; Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9
• Molecular Weight: Observed: 26 kD; Predicted: 27 kDa
• NCBI Official Full Name: linker for activation of T-cells family member 2
• NCBI Official Synonym Full Names: linker for activation of T cells family member 2
• NCBI Official Symbol: LAT2
• NCBI Official Synonym Symbols: LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• NCBI Protein Information: linker for activation of T-cells family member 2
• UniProt Protein Name: Linker for activation of T-cells family member 2
• Protein Family: Labaditin
• UniProt Gene Name: LAT2
• UniProt Synonym Gene Names: LAB; NTAL; WBS15; WBSCR15; WBSCR5

NCBI Description

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.