Fatty aldehyde dehydrogenase (Aldh3a2) Recombinant Protein | Aldh3a2 recombinant protein
Recombinant Rat Fatty aldehyde dehydrogenase (Aldh3a2)
NCBI and Uniprot Product Information
Uniprot Description
ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Oxidoreductase; Lipid Metabolism - fatty acid; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - pyruvate; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Lipid Metabolism - glycerolipid; EC 1.2.1.3; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine
Cellular Component: intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; peroxisome; nucleus; cytosol
Molecular Function: long-chain-alcohol oxidase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; long-chain-aldehyde dehydrogenase activity
Biological Process: phytol metabolic process; response to reactive oxygen species; epidermis development; central nervous system development; formaldehyde metabolic process; aldehyde metabolic process; sesquiterpenoid metabolic process; peripheral nervous system development
Research Articles on Aldh3a2
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Product Notes
The Aldh3a2 aldh3a2 (Catalog #AAA956062) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-463; Partial, provide the Cytoplasmic Topological domain. The amino acid sequence is listed below: MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTLQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY MIVNGGVEET TELLRQRFDH ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT CIAPDYILCE ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN FINDREKPLA LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW SKFFLLKQFN KGR . It is sometimes possible for the material contained within the vial of "Fatty aldehyde dehydrogenase (Aldh3a2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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